Anti-inflammatory effects of lipo-indomethacin, lipid emulsion of indomethacin
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Crocin exerts improving effects on indomethacin-induced small intestinal ulcer by antioxidant, anti-inflammatory and anti-apoptotic mechanisms
Crocin is a plant-derived carotenoid and bears potent antioxidant property. Ranitidine (a histamine H2 receptor blocker) is used for peptic ulcer treatment. The present study was planned to investigate the effects of crocin and ranitidine on indomethacin-induced ulcer in small intestine of rats. Animals were randomized into two major groups including indo-methacin (10.00 mg kg-1...
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To evaluate the residence of chitosan-coated emulsion (CE) containing indomethacin in tears, the drug retention of CE in tear fluid was compared with non-coated emulsion (NE) after instillation in rabbit eyes. CE had mean concentrations 3.6-fold and 3.8-fold higher than NE at 0.5 h and 0.75 h after instillation, respectively. Mean residence time and half-life of CE were lengthened to 1.5-fold a...
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Since its introduction in 1963 indomethacin (l-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetic acid) has been reported as an analgesic of value in the treatment of osteoarthitis (Hart and Boardman, 1963 ; Wanka et al., 1964; Percy et al., 1964) and ankylosing spondylitis (Katz et al., 1963 ; Hart and Boardman, 1963 ; Smyth and Godfrey, 1964; Percy et al., 1964; Rothermich, 1964; Michotte and...
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Pulmonary diffusing capacity and arterial blood Po(2) decrease in humans when 10% fat emulsion is infused. To study its effects on the pulmonary circulation and lung fluid balance, we infused 0.25 g/kg x h of a 10% fat emulsion (Intralipid, Cutter Laboratories, Inc., Berkeley, Calif.) into an awake sheep lung lymph preparation. The emulsion caused a sustained increase in pulmonary artery pressu...
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A patient had liver cirrhosis associated with marked hypoxemia. With administration of indomethacin (75 mg/day for six days), PaO2 was elevated up to 50 mm Hg from 44 mm Hg. At that time, dynamic pulmonary perfusion imaging revealed a plateau time course curve of MAA uptake in the lungs, as compared with findings obtained during the state of severe hypoxemia without indomethacin. These observat...
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ژورنال
عنوان ژورنال: Ensho
سال: 1982
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.2.4_477